Wolfram Syndrome

A hereditary condition characterized by multiple symptoms including those of DIABETES INSIPIDUS; DIABETES MELLITUS; OPTIC ATROPHY; and DEAFNESS. This syndrome is also known as DIDMOAD (first letter of each word) and is usually associated with VASOPRESSIN deficiency. It is caused by mutations in gene WFS1 encoding wolframin, a 100-kDa transmembrane protein.

Also Known As:

Syndrome, Wolfram; DIDMOADUD; Diabetes Insipidus and Mellitus with Optic Atrophy and Deafness; Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness; Wolfram Syndrome 1; DIDMOAD; DIDMOAD Syndrome

Otorhinolaryngologic Diseases: 204
- Ear Diseases: 267
  - Hearing Disorders: 329
    - Hearing Loss: 12667
      - Deafness: 5496
        Deaf-Blind Disorders: 70
        Wolfram Syndrome: 234
Nervous System Diseases: 14737
- Neurodegenerative Diseases: 44095
  - Nervous System Heredodegenerative Disorders: 62
    - Hereditary Optic Atrophies: 7
      - Wolfram Syndrome: 234
- Neurologic Manifestations: 7223
  - Sensation Disorders: 123
    - Vision Disorders: 3078
      - Blindness: 5709
        Deaf-Blind Disorders: 70
        Wolfram Syndrome: 234
    - Hearing Disorders: 329
      - Hearing Loss: 12667
        Deafness: 5496
        Deaf-Blind Disorders: 70
        Wolfram Syndrome: 234
- Cranial Nerve Diseases: 564
  - Optic Nerve Diseases: 2736
    - Optic Atrophy: 839
      - Hereditary Optic Atrophies: 7
        Wolfram Syndrome: 234
Eye Diseases: 3620
- Vision Disorders: 3078
  - Blindness: 5709
    - Deaf-Blind Disorders: 70
      - Wolfram Syndrome: 234
- Optic Nerve Diseases: 2736
  - Optic Atrophy: 839
    - Hereditary Optic Atrophies: 7
      - Wolfram Syndrome: 234
- Hereditary Eye Diseases: 19
  - Hereditary Optic Atrophies: 7
    - Wolfram Syndrome: 234
Urogenital Diseases: 129
- Urologic Diseases: 817
  - Kidney Diseases: 12764
    - Diabetes Insipidus: 2569
      - Wolfram Syndrome: 234
- Female Urogenital Diseases and Pregnancy Complications
  - Female Urogenital Diseases
    - Urologic Diseases: 817
      - Kidney Diseases: 12764
        Diabetes Insipidus: 2569
        Wolfram Syndrome: 234
- Male Urogenital Diseases
  - Urologic Diseases: 817
    - Kidney Diseases: 12764
      - Diabetes Insipidus: 2569
        Wolfram Syndrome: 234
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 960
- Congenital Abnormalities: 26404
  - Multiple Abnormalities: 213
    - Deaf-Blind Disorders: 70
      - Wolfram Syndrome: 234
- Inborn Genetic Diseases: 12342
  - Nervous System Heredodegenerative Disorders: 62
    - Hereditary Optic Atrophies: 7
      - Wolfram Syndrome: 234
  - Hereditary Eye Diseases: 19
    - Hereditary Optic Atrophies: 7
      - Wolfram Syndrome: 234
Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10634
  - Glucose Metabolism Disorders: 394
    - Diabetes Mellitus: 57856
      - Type 1 Diabetes Mellitus: 37660
        Wolfram Syndrome: 234
Endocrine System Diseases: 996
- Diabetes Mellitus: 57856
  - Type 1 Diabetes Mellitus: 37660
    - Wolfram Syndrome: 234
- Pituitary Diseases: 568
  - Diabetes Insipidus: 2569
    - Wolfram Syndrome: 234

Vyron Gorgogietas Selected Research

Vyron Gorgogietas Research Topics

Disease

Drug/Important Bio-Agent (IBA)